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DPN

SKU T7644-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 51 CAD through 563 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T7644

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H13NO2

Citations

– 1. Lu Z, Cao Y, Zhang D, et al. Discovery of Thieno [2, 3-e] indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. Journal of Medicinal Chemistry. 2022 2. Tong H, Fan S, Hu W, et al.Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A.Pharmacological Research.2024: 107376. 3. Zhang D, Lu Z, He Y, et al.Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer.Journal of Medicinal Chemistry.2024

References

– Marvin, J, Meyers, et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues[J]. Journal of Medicinal Chemistry, 2001.

CAS Number

– 1428-67-7

Molecular Weight

– C15H13NO2

Compound Purity

– 0.9901

SMILES

– Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1

Pathway

– Autophagy|||Endocrinology/Hormones|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.