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DP-15
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.
Products Details
Product Description
– DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]
For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.
Web ID
– T205043
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C42H44ClN9O5S
CAS Number
– 3033837-71-4
Molecular Weight
– C42H44ClN9O5S
SMILES
– CC=1C2=C(N3C([C@H](CC(=O)N4CCN(CC5CCN(CC5)C=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)CC4)N=C2C9=CC=C(Cl)C=C9)=NN=C3C)SC1C
Target
– NF-κB
Pathway
– PROTAC|||Apoptosis|||Chromatin/Epigenetic
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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