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Dapolsertib

SKU T39085-1 mg Category Small Compound Brand: TargetMol

Price range: 160 CAD through 2,976 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Dapolsertib (SEL24-B489) is an orally bioavailable and potent PIM and FLT3-ITD inhibitor, inhibiting PIM1, PIM2, and PIM3, decreasing PIM substrate phosphorylation, and inducing dose-dependent apoptosis in leukemia cells.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T39085

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H18Br2N4O2

References

– Wojciech Czardybon, A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia. Oncotarget. 2018 Mar 30;9(24):16917-16931.

CAS Number

– 1616359-00-2

Molecular Weight

– C15H18Br2N4O2

Compound Purity

– 0.9961

SMILES

– O=N(=O)C=1C(Br)=C(Br)C=C2C1N=C(N2C(C)C)C3CCNCC3

Pathway

– Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.