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Curcumin

SKU T1516-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 48 CAD through 203 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 g 1 mL * 10 mM (in DMSO)100 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1516

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H20O6

Citations

– 1. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway .Resveratrol inhibits proliferation,migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 2. Gou X, Tian D, Wei J, et al. New Drimane Sesquiterpenes and Polyketides from Marine-Derived Fungus Penicillium sp. TW58-16 and Their Anti-Inflammatory and α-Glucosidase Inhibitory Effects. Marine Drugs. 2021, 19(8): 416. 3. Tian D, Cao L, Li Q, et al. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens. Bioorganic Chemistry. 2021, 107: 104604 4. Liu Y P, Xie Z, Guan R Q, et al. Syzysamalactone, an Unusual 11-Carbon δ‑Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple). Journal of Natural Products. 2022 5. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15 6. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1. 7. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 8. Wang W, Zeng Z, Zhang J, et al.A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma.Natural Product Communications.2023, 18(5): 1934578X231169370. 9. Bu H, Wang B, Wu Y, et al.Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.Environmental Science and Pollution Research.2023: 1-17. 10. Zhang S, Tian D, Xia Z, et al.Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway.Journal of Ethnopharmacology.2024: 118236.

References

– Li Y, et al. Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway. BMC Cancer. 2018 Dec 10;18(1):1230.

CAS Number

– 458-37-7

Molecular Weight

– C21H20O6

Compound Purity

– 0.9898

SMILES

– COC1=CC(C=CC(=O)CC(=O)C=CC2=CC(OC)=C(O)C=C2)=CC=C1O

Target

– Others

Pathway

– Immunology/Inflammation|||Apoptosis|||Microbiology/Virology|||Autophagy|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.