Crenolanib

SKU T2677-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 85 CAD through 747 CAD

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Product Description

– Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).

Web ID

– T2677

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H29N5O2

Citations

– 1. Lin Q, Qin M, Zhao S, et al. The roles of PDGFRα signaling in the postnatal development and functional maintenance of the SMC‐ICC‐PDGFRα+ cell (SIP) syncytium in the colon. Neurogastroenterology & Motility. 2019, 31(5): e13568 2. Shi Y H, Liu Z D, Ma M J, et al.Platelet‐Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism.Advanced Science.2024: 2407069.

References

– Heinrich MC, et al.Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors. Clin Cancer Res, 2012, Jun 27.

CAS Number

– 670220-88-9

Molecular Weight

– C26H29N5O2

Compound Purity

– 0.9745

SMILES

– CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1

Pathway

– Angiogenesis|||Tyrosine Kinase/Adaptors|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Crenolanib

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