Download Files:

Colchicine

SKU T0320-100 mg Category Natural Product Brand: TargetMol

Price range: 54 CAD through 102 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

100 mg 200 mg 500 mg

Clear

Products Details

Product Description

– Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of ventilation and rheumatic diseases.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0320

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H25NO6

Citations

– 1. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 2. Wang H, Liang Y, Zhao L, et al.miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2023: 166821. 3. Yuan W, Liu T, Wang Y, et al.Autophagy induced by PP121 alleviates MSU crystal-induced acute gouty arthritis via inhibition of the NLRP3 inflammasome.International Immunopharmacology.2023, 123: 110756. 4. Hou Z, Lin S, Du T, et al.S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer.Pharmaceuticals.2023, 16(5): 749. 5. Dong H, Sun H, Zheng J. A microchip for integrated single-cell genotoxicity assay. Talanta. 2016, 161: 804-811. 6. Pan H, Lin Y, Dou J, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Proliferation. 2020, 53(9): e12868 7. Ai, Yongqiang, et al. The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice. Frontiers in Pharmacology. 12 (2021) 8. Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Frontiers in Immunology. 2020 Dec 7;11:580593. doi: 10.3389 9. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 10. Li X, Liu B, Wen Y, et al.Coordination of RAB-8 and RAB-11 during unconventional protein secretion.Journal of Cell Biology.2023, 223(2): e202306107.

References

– Cho JH, et al. Anticancer Effects of Colchicine on Hypopharyngeal Cancer. Anticancer Res. 2017 Nov;37(11):6269-6280.

CAS Number

– 64-86-8

Molecular Weight

– C22H25NO6

Compound Purity

– 0.9988

SMILES

– COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

Target

– Others

Pathway

– Apoptosis|||Autophagy|||Cytoskeletal Signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.