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CHDI-390576
$120 – $1,050
Products Details
Product Description
– CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1].
Web ID
– HY-119939
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H13F4N3O2
References
– [1]Luckhurst CA, et al. Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg Med Chem Lett. 2019 Jan 1;29(1):83-88.
CAS Number
– 1629729-98-1
Molecular Weight
– 391.32
Compound Purity
– 99.42
SMILES
– O=C(NO)C(C1=C(F)C=CC=C1)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– HDAC
Isoform
– HDAC1;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
