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Ceralasertib

SKU T3338-1 mg Category Small Compound Brand: TargetMol

Price range: 69 CAD through 702 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Ceralasertib (AZD6738) is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3338

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H24N6O2S

Citations

– 1. Lei H, Xu H Z, Shan H Z, et al. Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nature Communications. 2021 Jan 4;12(1):51. doi: 10.1038/s41467-020-20259-0. 2. Lei H, Xu H Z, Shan H Z, et al. Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nature Communications. 2021 Jan 4;12(1):51. doi: 10.1038/s41467-020-20259-0. 3. Liang J, Niu Z, Zhang B, et al. p53-dependent elimination of aneuploid mitotic offspring by entosis. Cell Death & Differentiation. 2020: 1-15 4. Liang J, Niu Z, Zhang B, et al Liang J, Niu Z, Zhang B, et al. p53-dependent elimination of aneuploid mitotic offspring by entosis. Cell Death & Differentiation. 2020: 1-15. 5. Gao X, Ren X, Wang F, et al.Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma.Scientific Reports.2024, 14(1): 9509. 6. Xu L, Chen Y, Wu T, et al.DNA damage-mediated FTO downregulation promotes CRPC progression by inhibiting FOXO3a via an m6A-dependent mechanism.iScience.2024

References

– Vendetti FP, et al. Oncotarget. 2015. doi: 10.18632/oncotarget.6247.

CAS Number

– 1352226-88-0

Molecular Weight

– C20H24N6O2S

Compound Purity

– 0.9976

SMILES

– C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)S(C)(=N)=O

Target

– Others

Pathway

– PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.