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CAY10746
$220 – $3,580
Products Details
Product Description
– CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR)[1].
Web ID
– HY-139170
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Molecular Formula
– C26H23N3O5
References
– [1]Lanying Zhao, et al. Discovery of 4 H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. J Med Chem. 2019 Dec 12;62(23):10691-10710.
CAS Number
– 2247240-76-0
Molecular Weight
– 457.48
Compound Purity
– 99.77
SMILES
– O=C1C=COC2=CC(OCC(NC3=CC(NC(C4=CC=C(N(C)C)C=C4)=O)=CC=C3)=O)=CC=C12
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– ROCK
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
