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Capsaicin

SKU T1062-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 80 CAD through 120 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)100 mg 50 mg

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Products Details

Product Description

– Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1062

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H27NO3

Citations

– 1. Lu J, Zhou W, Dou F, et al. TRPV1 sustains microglial metabolic reprogramming in Alzheimer’s disease. EMBO reports. 2021, 22(6): e52013. 2. Lu J, Wang C, Cheng X, et al. A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease. Journal of Neuroinflammation. 2022, 19(1): 1-21 3. Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12: 763866-763866. 4. Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12 5. Tang K, Zhang X, Guo Y. Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry. Acta Pharmaceutica Sinica B. 2020 6. Xia J, Gu L, Guo Y, et al. Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice. Frontiers in Cellular and Infection Microbiology. 2021, 11. 7. Wang C, Lu J, Sha X, et al.TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia.Experimental & Molecular Medicine.2023: 1-17. 8. Lu J, Wu K, Sha X, et al.TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer’s disease.Translational Neurodegeneration.2024, 13(1): 52. 9. Sha X, Lin J, Wu K, et al.The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease.Cell Death & Disease.2025, 16(1): 14. 10. The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease[J]. Cell Death & Disease, 2025, 16(1): 14.

References

– Le TD, et al. Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. Yonsei Med J. 2012 Jul 1;53(4):834-4doi: 10.3349/ymj.2012.53.4.834. Erratum in: Yonsei Med J. 2012 Nov 1;53(6):1228.

CAS Number

– 404-86-4

Molecular Weight

– C18H27NO3

Compound Purity

– 0.9927

SMILES

– C(NC(CCCC/C=C/C(C)C)=O)C1=CC(OC)=C(O)C=C1

Target

– Thyroid hormone receptor(THR)

Pathway

– Autophagy|||Apoptosis|||Membrane transporter/Ion channel

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.