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Canakinumab
$600 – $1,200
Products Details
Product Description
– Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].
Web ID
– HY-108810
Storage Temperature
– Store at -80°C for 2 years
Shipping
– Dry Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– N/A
References
– [1]Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. |[2]Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015;7(6):1151-60.
CAS Number
– 914613-48-2
Molecular Weight
– N/A
Compound Purity
– 99.64
SMILES
– [Canakinumab]
Clinical Information
– Phase 4
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related
Pathway
– Immunology/Inflammation
Product type
– Inhibitory Antibodies
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
