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Caffeic Acid Phenethyl Ester

SKU T6429-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 53 CAD through 277 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6429

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H16O4

Citations

– 1. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. 2. Osés S M, Marcos P, Azofra P, et al. Phenolic Profile, Antioxidant Capacities and Enzymatic Inhibitory Activities of Propolis from Different Geographical Areas: Needs for Analytical Harmonization. Antioxidants. 2020, 9(1): 75 3. Yu G, Jiao Y, Huang J J, et al. Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2. Experimental and Therapeutic Medicine. 2021 May;21(5):441. doi: 10.3892/etm.2021.9879. Epub 2021 Feb 28. 4. Li W, Yang C, Shi Z, et al.Caffeic Acid Phenethyl Ester Inhibits Ubiquitination and Degradation of p53 and Blocks Cervical Cancer Cell Growth.Current Molecular Medicine.2023 5. Gargouri W, Elleuche M, Fernández-Muiño M A, et al.Microencapsulated propolis powder: A promising ingredient of chewing gum.Powder Technology.2024: 119777.

References

– Natarajan K, et al. Proc Natl Acad Sci U S A. 1996, 93(17), 9090-9095.

CAS Number

– 104594-70-9

Molecular Weight

– C17H16O4

Compound Purity

– 0.9918

SMILES

– Oc1ccc(C=CC(=O)OCCc2ccccc2)cc1O

Pathway

– Apoptosis|||NF-κB

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.