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BMS-1

SKU T3655-1 mg Category Small Compound Brand: TargetMol

Price range: 77 CAD through 2,448 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3655

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H33NO5

Citations

– 1. Zhao Y, Hao C, Li M, et al. PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis. Biomedicine & Pharmacotherapy. 2022, 148: 112768. 2. Choi J G, Kim Y S, Kim J H, et al. Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model. Frontiers in immunology. 2020 Nov 5;11:598556. doi: 10.3389

References

– Chupak Louis S,et al. From PCT Int. Appl. (2015), WO 2015034820 A1 20150312.

CAS Number

– 1675201-83-8

Molecular Weight

– C29H33NO5

Compound Purity

– 0.9986

SMILES

– COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CN1CCCC[C@H]1C(O)=O

Pathway

– Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.