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BLU-945

SKU T9754-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 155 CAD through 2,528 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs). BLU-945 inhibits EGFR phosphorylation in EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S mutant cell lines. BLU-945 can be used in lung cancer research, including non-small cell lung cancer (NSCLC).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T9754

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H37FN6O3S

Citations

– 1. Liang J, Bi G, Sui Q, et al.Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.Cell Reports.2024, 43(2).

References

– John Emmerson Campbell, et al. Inhibitors of mutant forms of egfr. Patent WO2021133809A1.

CAS Number

– 2660250-10-0

Molecular Weight

– C28H37FN6O3S

Compound Purity

– 0.9916

SMILES

– CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1

Pathway

– Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.