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Bisdemethoxycurcumin

SKU TL0007-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 50 CAD through 635 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– TL0007

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H16O4

References

– Fiala, M., Liu, P.T., Espinosa-Jeffrey, A., et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007).

CAS Number

– 24939-16-0

Molecular Weight

– C19H16O4

Compound Purity

– 0.9942

SMILES

– Oc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)cc1

Pathway

– Stem Cells|||Chromatin/Epigenetic|||Cytoskeletal Signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.