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BI-2865

SKU T72062-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 365 CAD through 2,960 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants[1]. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants, with an average IC50 value of approximately 140 nM.[1]

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T72062

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H27N7O2S

Citations

– 1. Guo Y, Tian J, Guo Y, et al.Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.Cell Reports.2023, 42(12). 2. Guo Y, Hu C, Cai K, et al.KRAS inhibitors may prevent colorectal cancer metachronous metastasis by suppressing TGF‑β mediated epithelial‑mesenchymal transition.Molecular Medicine Reports.2025, 31(1): 1-12.

References

– Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023;619(7968):160-166.

CAS Number

– 2937327-93-8

Molecular Weight

– C23H27N7O2S

Compound Purity

– 0.9939

SMILES

– C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4

Pathway

– GPCR/G Protein|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.