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Bafilomycin A1

SKU T6740-160 μL * 1 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 157 CAD through 1,592 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

160 μL * 1 mM (in DMSO)500 μg 1 mg 10 mg 5 mg

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Products Details

Product Description

– Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6740

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C35H58O9

Citations

– 1. Zhang Y, Ding Y, Li M, et al. MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B. Acta Pharmaceutica Sinica B. 2021 2. Du L, Wu Y, Han X, et al. NICE-3-knockdown induces cell cycle arrest and autophagy in lung adenocarcinoma cells via the AKT/mTORC1 signaling pathway. Experimental and Therapeutic Medicine. 2021, 21(6): 1-8 3. Wang J, Su Q, Wu Q, et al. Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells. Archives of Pharmacal Research. 2021: 1-12. 4. Su Q, Wu Q, Chen K, et al. Induction of Estrogen Receptor β-mediated Autophagy Sensitizes Breast Cancer Cells to TAD1822-7, a Novel Biphenyl Urea Taspine Derivative. Molecular Biology Reports. 2021 5. Wang J, Yan J T, Zeng S T, et al.Revealing Mitochondrion–Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe.Analytical Chemistry.2023 6. Gao C, Shi Q, Pan X, et al.Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis.Cell Reports.2024, 43(3). 7. Bao Q, Wang A, Hong W, et al.The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition.Cell Communication and Signaling.2024, 22(1): 247. 8. Wu A, Yan J, Su T, et al.Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition.Oncology Research.2024, 32(7): 1197. 9. Li X, Hu M, Zhou X, et al.Hederagenin inhibits mitochondrial damage in Parkinson’s disease via mitophagy induction.Free Radical Biology and Medicine.2024 10. Zhu Y, Kang N, Zhang L, et al.Targeting and degradation of OTUB1 by Erianin for antimetastasis in esophageal squamous cell carcinoma.Phytomedicine.2024: 155969.

References

– Ohta T, et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-J Pathol. 1998 Jul;185(3):324-30.

CAS Number

– 88899-55-2

Molecular Weight

– C35H58O9

Compound Purity

– 0.9936

SMILES

– [H][C@@]1(OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

Pathway

– Microbiology/Virology|||Apoptosis|||Autophagy|||Membrane transporter/Ion channel

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.