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AX-024 (hydrochloride)
$154 – $1,540
Products Details
Product Description
– AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
Web ID
– HY-107390A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H23ClFNO2
References
– [1]Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.
CAS Number
– 1704801-24-0
Molecular Weight
– 375.86
Compound Purity
– 99.75
SMILES
– COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 33 mg/mL (ultrasonic;warming)|H2O : 16.67 mg/mL (ultrasonic)
Target
– IFNAR;Interleukin Related;TNF Receptor
Isoform
– CD40;IL-10;IL-17;IL-6
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
