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ATX inhibitor 5
$350 – $2,500
Products Details
Product Description
– ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].
Web ID
– HY-133019
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H18ClF3N6O
References
– [1]Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904.
CAS Number
– 2402772-45-4
Molecular Weight
– 474.87
Compound Purity
– 99.20
SMILES
– O=C(N/N=C/C1=CC=C(Cl)C=C1)N(C2)CCC3=C2C(NC4=CC=CC(C(F)(F)F)=C4)=NC=N3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Phosphodiesterase (PDE)
Isoform
– Autotaxin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
