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ATN-161 (trifluoroacetate salt)
$110 – $810
Products Details
Product Description
– ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
Web ID
– HY-13535A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H36F3N9O10S
Citations
– Acs Biomater Sci Eng. 2023 Apr 24.|Cell Prolif. 2021 Apr;54(4):e13012.|Colloids Surf B Biointerfaces. 20 November 2021, 112227.|Stem Cell Res Ther. 2022 Jul 18;13(1):327.|Cancer Cell. 2019 Jan 14;35(1):64-80.e7. |Sci Signal. 2022 Dec 6;15(763):eabn2743.
References
– [1]Stoeltzing O, et al. Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer. 2003 Apr 20;104(4):496-503.|[2]Wang W, et al. The antiangiogenic effects of integrin alpha5beta1 inhibitor (ATN-161) in vitro and in vivo. Invest Ophthalmol Vis Sci. 2011 Sep 14;52(10):7213-20.
CAS Number
– 904763-27-5
Molecular Weight
– 711.67
Compound Purity
– 95.0
SMILES
– FC(F)(C(O)=O)F.O=C(N)C[C@@H](C(N)=O)NC([C@H](CS)NC([C@H](CO)NC([C@H](CC1=CNC=N1)NC([C@H]2N(C(C)=O)CCC2)=O)=O)=O)=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Integrin
Pathway
– Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
