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AT7519

SKU T6205-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 83 CAD through 360 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T6205

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H17Cl2N5O2

Citations

– 1. Kazi A, Chen L, Xiang S, et al. Global Phosphoproteomics reveal CDK suppression as a vulnerability to KRAS addiction in Pancreatic Cancer. Clinical Cancer Research. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20. 2. Zhao W, Zhang L, Zhang Y, et al.The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.Cell Death & Disease.2023, 14(1): 11. 3. Long Y, Jia X, Chu L.Insight into the structure, function and the tumor suppression effect of gasdermin E.Biochemical Pharmacology.2024: 116348.

References

– Squires MS, et al. Mol Cancer Ther, 2009, 8(2), 324-332.

CAS Number

– 844442-38-2

Molecular Weight

– C16H17Cl2N5O2

Compound Purity

– 0.9967

SMILES

– N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3CCNCC3)=O)=NNC2

Pathway

– Cell Cycle/Checkpoint|||Apoptosis|||PI3K/Akt/mTOR signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.