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Products Details
Product Description
– Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC50 of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity[1].
Web ID
– HY-149944
Shipping
– Room temperature
Molecular Formula
– C21H21ClF2N4O2
References
– [1]Qin H, et al. Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluoroazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain. Eur J Med Chem. 2023 Jun 5;254:115371.
Molecular Weight
– 434.87
SMILES
– CC1=C(C=C(C(N2CCCC(F)(CC2)F)=N1)C(NC3=CC4=C(CNC4=O)C=C3)=O)Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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