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AMG-1694

SKU T14212-1 mg Category Small Compound Brand: TargetMol

Price range: 365 CAD through 3,616 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T14212

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H30F3N3O4S2

References

– Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.

CAS Number

– 1361217-07-3

Molecular Weight

– C23H30F3N3O4S2

Compound Purity

– 0.9797

SMILES

– C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4

Target

– Apoptosis|||Akt

Pathway

– Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.