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Alvespimycin (hydrochloride)
$42 – $541
Products Details
Product Description
– Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
Web ID
– HY-12024
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H49ClN4O8
Citations
– Authorea. April 10, 2021.|bioRxiv. 2021 Jan 27.|Br J Pharmacol. 2021 Nov;178(22):4485-4500.|Front Pharmacol. 14 January 2022.|Nat Commun. 2021 Jul 22;12(1):4457.|Acs Biomater Sci Eng. 2021 Oct 12.|Cell Death Dis. 2022 Jan 21;13(1):73.|Exp Ther Med. February 10, 2022.|Friedrich-Alexander University Erlangen-Nuremberg. 2016 Sep 14.|NPJ Precis Oncol. 2023 May 18;7(1):44.|Pharmacol Res. 2020 Jan;151:104512.|Sci Rep. 2021 May 26;11(1):11057.|Theranostics. 2020 Jul 9;10(18):8415-8429.
References
– [1]Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.|[2]Henke A, et al. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24;8(9). pii: E77.|[3]Hertlein E, et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood. 2010 Jul 8;116(1):45-53.
CAS Number
– 467214-21-7
Molecular Weight
– 653.21
Compound Purity
– 99.55
SMILES
– C/C1=CC=C/[C@@H]([C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC(C(C(NC1=O)=CC2=O)=O)=C2NCCN(C)C)C)OC)O[H])C)OC(N)=O)OC.Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 4.76 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;HSP
Isoform
– HSP90
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
