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Products Details
Product Description
– ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1].
Web ID
– HY-128569
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H25FN6O3
References
– [1]Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62(10):4915-4935.
CAS Number
– 2351929-66-1
Molecular Weight
– 464.49
SMILES
– O=C(C1=CN(C2=NNC(C)=C2)C3=NC(O[C@H](C4=NC=C(F)C=C4)C)=CC=C31)N5C[C@H](C)OCC5
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK)
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
