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Products Details
Product Description
– Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].
Web ID
– HY-12177S
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H49D6N3O8
References
– [1]Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754-758.|[2]Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31.
Molecular Weight
– 615.83
SMILES
– O=C(NCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(N)=O)[C@H](C(C)C)C[C@H](O)[C@@H](N)C[C@@H](C(C)C)CC1=CC(OCCCOC)=C(OC)C=C1.O=C(O)/C=C/C(O)=O.[1/2]
Clinical Information
– No Development Reported
Research Area
– Cancer; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;Isotope-Labeled Compounds;Renin
Pathway
– Autophagy;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
