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AICAR

SKU T1477-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 48 CAD through 80 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)25 mg 50 mg

Clear

Products Details

Product Description

– AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1477

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C9H14N4O5

Citations

– 1. Rao X S, Cong X X, Gao X K, et al. AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake. Cell Death & Differentiation. 2021: 1-21. 2. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94. 3. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Research & Therapy. 2020, 11(1): 1-22 4. Liang X, Liang J, Zhang S, et al.Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.Science of The Total Environment.2024: 169919.

References

– Corton JM, et al. Eur J Biochem, 1995, 229(2), 558-565.

CAS Number

– 2627-69-2

Molecular Weight

– C9H14N4O5

Compound Purity

– 0.9987

SMILES

– NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N

Target

– HDAC

Pathway

– Autophagy|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.