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Products Details
Product Description
– AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson’s disease[1].
Web ID
– HY-119857
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C23H13Cl2N3O2
References
– [1]Outeiro TF, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease. Science. 2007;317(5837):516-519.
CAS Number
– 304896-21-7
Molecular Weight
– 434.27
SMILES
– O=C(NC1=CC=CC2=C1N=CC=C2)/C(C#N)=C/C3=CC=C(O3)C4=CC(Cl)=CC=C4Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Sirtuin
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
