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AG490

SKU T2600-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 69 CAD through 475 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 50 mg 500 mg

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Products Details

Product Description

– AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2600

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H14N2O3

Citations

– 1. Pan Z, Wang K, Wang X, et al. Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer. 2022, 21(1): 1-17. 2. Ma Z, Zheng J C, Li T, et al. Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts. Frontiers in Physiology. 2022: 474 3. Qin, Zhi-zhi, et al. Mangiferin Promotes Bregs Level, Activates Nrf2 Antioxidant Signaling, and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro.. Current Medical Science. (2021): 1-11. 4. Tian X, Liu F, Wang Z, et al.Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.Journal of Ethnopharmacology.2023: 117577. 5. Fan Y, Huang S, Li S, et al.The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias.Cell Reports Medicine.2024

References

– Gazit A, et al. J Med Chem, 1991, 34(6), 1896-1907.

CAS Number

– 133550-30-8

Molecular Weight

– C17H14N2O3

Compound Purity

– 0.997

SMILES

– C(=C(/C(NCC1=CC=CC=C1)=O)C#N)C2=CC(O)=C(O)C=C2

Pathway

– Autophagy|||Angiogenesis|||Stem Cells|||Chromatin/Epigenetic|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.