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Adavosertib
Price range: 64 CAD through 462 CAD
Products Details
Product Description
– Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
Web ID
– T2077
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H32N8O2
Citations
– 1. Al‐Jamaei A A H, de Visscher J G A M, Ramadugula V S, et al. WEE1 kinase inhibitor MK‐1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status. Oral Diseases. 2022
2. Gao X, Ren X, Wang F, et al.Immunotherapy and drug sensitivity predictive roles of a novel prognostic model in hepatocellular carcinoma.Scientific Reports.2024, 14(1): 9509.
3. Esposito E, Marra G, Catalano R, et al.Therapeutic potential of targeting the FLNA‐regulated Wee1 kinase in adrenocortical carcinomas.International Journal of Cancer.2024
References
– Hirai H, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther. 2009 Nov;8(11):2992-3000.
CAS Number
– 955365-80-7
Molecular Weight
– C27H32N8O2
Compound Purity
– 0.9986
SMILES
– C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5
Target
– Others
Pathway
– Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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