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ACY-957
$310 – $2,200
Products Details
Product Description
– ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].
Web ID
– HY-104008
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C24H23N5OS
References
– [1]Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.
CAS Number
– 1609389-52-7
Molecular Weight
– 429.54
Compound Purity
– 99.87
SMILES
– O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– HDAC
Isoform
– HDAC1;HDAC2;HDAC3
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
