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Products Details
Product Description
– AcLysValCit-PABC-DMAE-SW-163D is a agent-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1].
Web ID
– HY-114325
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C85H113N19O22S2
References
– [1]Ratnayake AS, et al. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjug Chem. 2018 Dec 13. doi: 10.1021/acs.bioconjchem.8b00843.
CAS Number
– 2411007-69-5
Molecular Weight
– 1817.05
SMILES
– C[C@H](NC1=O)C(N([C@H](C(N([C@]2(C(OC[C@@H](NC(C3=C(C=C4C(C=CC=C4)=N3)O)=O)C(N[C@H](C(N(C)[C@@H](CS5)C(N(C)[C@]6(C(OC[C@H]1NC(C7=C(C=C8C(C=CC=C8)=N7)OC(N(CCN(C(OCC9=CC=C(C=C9)NC([C@@H](NC([C@@H](NC([C@@H](CCCCN)NC(C)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)C)C)=O)=O)=O)[C@H](C6)C)=O)=O)C)=O)=O)[C@H](C2)C)C)=O)[C@H]5SC)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug-Linker Conjugates for ADC
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
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