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ABT-737
Price range: 102 CAD through 1,021 CAD
Products Details
Product Description
– ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w (EC50=30.3 nM/78.7 nM/197.8 nM). ABT-737 exhibits antitumor activity and anti-aging activity.
Web ID
– T2099
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C42H45ClN6O5S2
Citations
– 1. Zhang W, Li X, Jiang M, et al.SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.Journal of Leukocyte Biology.2023: qiad020.
2. Li R, Li Y, Jiang K, et al.Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.Cell Metabolism.2024
References
– Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.
CAS Number
– 852808-04-9
Molecular Weight
– C42H45ClN6O5S2
Compound Purity
– 0.9973
SMILES
– CN(C)CCC(CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1
Pathway
– Autophagy|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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