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A 83-01

SKU T3031-5 mg Category Small Compound Brand: TargetMol

Price range: 83 CAD through 1,502 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cultures.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3031

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H19N5S

Citations

– 1. Fu G B, Huang W J, Zeng M, et al. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Research. 2019, 29(1): 8-22 2. Ma X, Lu Y, Zhou Z, Human expandable pancreatic progenitor–derived β cells ameliorate diabetes. Science Advances. 2022, 8(8): eabk1826. 3. He W, Zhu X, Xin A, et al. Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion. Cell & Bioscience. 2022, 12(1): 1-20. 4. Zhang S W, Chen W, Lu X, et al. An efficient and user‐friendly method for cytohistological analysis of organoids. Journal of Tissue Engineering and Regenerative Medicine. 2021 5. Tan Z, Pan K, Sun M, et al.CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.Cell Death & Differentiation.2024: 1-16. 6. Chen Y, Wu Y, Sun H, et al.Human liver progenitor-like cells-derived extracellular vesicles promote liver regeneration during acute liver failure.Cell Biology and Toxicology.2024, 40(1): 1-21. 7. A gastric cancer patient-derived three-dimensional cell spheroid culture model

References

– Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.

CAS Number

– 909910-43-6

Molecular Weight

– C25H19N5S

Compound Purity

– 0.982

SMILES

– Cc1cccc(n1)-c1nn(cc1-c1ccnc2ccccc12)C(=S)Nc1ccccc1

Pathway

– Tyrosine Kinase/Adaptors|||Stem Cells|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.