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A-740003

SKU T3690-5 mg Category Small Compound Brand: TargetMol

Price range: 54 CAD through 182 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuroblastoma tumor growth in mice.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T3690

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H30N6O3

Citations

– 1. Xiao Z, Xu M, Lan L, et al. Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis. Molecular Pain. 2022, 18: 17448069221106844 2. Tian C, Han X, He L, et al. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and Cellular Biochemistry. 2020: 1-14

References

– Kim, J., Ryu, H., & Kang, T. (2011). P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus. Journal Of Neuroinflammation, 8(1), 62. doi: 10.1186/1742-2094-8-62

CAS Number

– 861393-28-4

Molecular Weight

– C26H30N6O3

Compound Purity

– 0.9968

SMILES

– COc1ccc(CC(=O)NC(NC(Nc2cccc3ncccc23)=NC#N)C(C)(C)C)cc1OC

Pathway

– Membrane transporter/Ion channel|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.