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5-Azacytidine
$60 – $119
Products Details
Product Description
– 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].
Web ID
– HY-10586
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C8H12N4O5
References
– [1]Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.|[2]Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2′-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8.|[3]Christman JK. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.|[4]Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9.
CAS Number
– 320-67-2
Molecular Weight
– 244.20
Compound Purity
– 99.79
SMILES
– OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)N=C2)=O)O1
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : ≥ 31 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Target
– Antibiotic;Autophagy;Bacterial;DNA Methyltransferase;Nucleoside Antimetabolite/Analog
Isoform
– DNMT1
Pathway
– Anti-infection;Autophagy;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
