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3-TYP

SKU T4108-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 53 CAD through 1,093 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T4108

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C7H6N4

Citations

– 1. Lahiri T, Brambilla L, Andrade J, et al. Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer. Molecular Oncology. 2021 May;15(5):1432-1449. doi: 10.1002/1878-0261.12928. Epub 2021 Apr 10. 2. Zhang Y, Gao F, Gong H, et al.Intermittent fasting attenuates obesity-related atrial fibrillation via SIRT3-mediated insulin resistance mitigation.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2023: 166638. 3. Xue K H, Jiang Y F, Bai J Y, et al.Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect.Redox Report.2023, 28(1): 2251234. 4. Shi Y, Xing L, Zheng R, et al.Butyrate attenuates high-fat diet induced glomerulopathy through GPR43-Sirt3 pathway.The British journal of nutrition.2024: 1-27.

References

– Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51

CAS Number

– 120241-79-4

Molecular Weight

– C7H6N4

Compound Purity

– 0.9916

SMILES

– c1[nH]nnc1-c1cccnc1

Pathway

– DNA Damage/DNA Repair|||Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.