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3-Methyladenine

SKU T1879-25 mg Category Natural Product Brand: TargetMol

Price range: 56 CAD through 426 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– 3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50 = 60 μM) and class III VPS34 (IC50 = 25 μM). 3-Methyladenine inhibits autophagy.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1879

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C6H7N5

Citations

– 1. Yan C, Zheng L, Jiang S, et al.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.Cancer Cell.2023 2. Liu X, Fang Y, Lv X, et al.Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.Cell Death & Differentiation.2023: 1-15. 3. Zhang J, Zhou E C, He Y, et al.ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation.Cell Reports.2023, 42(3). 4. Wang X, Ji Y, Qi J, et al.Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells.Cell Death & Disease.2023, 14(8): 1-13. 5. Long T, Chen X, Zhang Y, et al.Protective effects of Radix Stellariae extract against Alzheimer’s disease via autophagy activation in Caenorhabditis elegans and cellular models.Biomedicine & Pharmacotherapy.2023, 165: 115261. 6. Wu Z, Lin C, Zhang F, et al.TIGD1 Function as a Potential Cuproptosis Regulator Following a Novel Cuproptosis-Related Gene Risk Signature in Colorectal Cancer.Cancers.2023, 15(8): 2286. 7. Zhang W, Li X, Jiang M, et al.SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.Journal of Leukocyte Biology.2023: qiad020. 8. Jiao J, Ruan L, Cheng C, et al.Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation.Molecular Medicine.2023, 29(1): 1-17. 9. Cao P, Wang Y, Zhang C, et al.Quercetin ameliorates non-alcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy.The Journal of Nutritional Biochemistry.2023: 109414. 10. Zhang Y, Wu K, Liu Y, et al.UHRF2 promotes the malignancy of hepatocellular carcinoma by PARP1 mediated autophagy.Cellular Signalling.2023: 110782.

References

– Hou H, et al. Inhibitors of phosphatidylinositol 3′-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.

CAS Number

– 5142-23-4

Molecular Weight

– C6H7N5

Compound Purity

– 0.9965

SMILES

– Cn1cnc(N)c2ncnc12

Target

– Others

Pathway

– Metabolism|||Autophagy|||PI3K/Akt/mTOR signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.