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3′-Azido-3′-deoxy-5-methylcytidine
$93 – $750
Products Details
Product Description
– 3′-Azido-3′-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3′-Azido-3′-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3′-Azido-3′-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-111640
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C10H14N6O4
References
– [1]Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948.
CAS Number
– 1282040-14-5
Molecular Weight
– 282.26
Compound Purity
– 99.15
SMILES
– O[C@@H]1[C@H](N=[N+]=[N-])[C@@H](CO)O[C@H]1N2C=C(C)C(N)=NC2=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
