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2’MeO6MF
$316
Only 1000 item(s) left in stock.
Products Details
Product Description
– 2’MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2’MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2’MeO6MF has anxiolytic and psychomotor stabilizing properties. 2’MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
Web ID
– HY-131997
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H14O3
References
– [1]Karim N, et, al. 2′-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol. 2012 Feb;165(4):880-96.|[2]Clarkson AN, et, al. The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. J Cereb Blood Flow Metab. 2019 Jul;39(7):1266-1282.
CAS Number
– 89112-85-6
Molecular Weight
– 266.29
SMILES
– O=C1C=C(C2=CC=CC=C2OC)OC3=CC=C(C)C=C13
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– GABA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
