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2-Methoxyestradiol

SKU T2220-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 30 USD through 82 USD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)100 mg 200 mg 25 mg 50 mg

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Products Details

Product Description

– 2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2220

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H26O3

Citations

– 1. Chen X C, Tang G X, Luo W H, et al. Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. Journal of the American Chemical Society. 2021 2. Guo Y, Tian J, Guo Y, et al.Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.Cell Reports.2023, 42(12). 3. Zheng B X, Long W, Zheng W, et al.Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.Journal of Medicinal Chemistry.2024

References

– Rao PN, et al. Steroids. 2002, 67(13-14), 1079-1089.

CAS Number

– 362-07-2

Molecular Weight

– C19H26O3

Compound Purity

– 0.9995

SMILES

– [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]

Pathway

– NF-κB|||Autophagy|||Angiogenesis|||Chromatin/Epigenetic|||Apoptosis|||Immunology/Inflammation|||Metabolism|||Cytoskeletal Signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.