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2-D08
$66 – $585
Products Details
Product Description
– 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
Web ID
– HY-114166
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H10O5
References
– [1]Kim YS, et al. Synthesis of 2′,3′,4′-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.|[2]Fujino N, et al. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017 Sep;97(9):1047-1062.|[3]Ghosh H, et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016 Nov 7;7:13365. doi: 10.1038/ncomms13365.
CAS Number
– 144707-18-6
Molecular Weight
– 270.24
Compound Purity
– 98.44
SMILES
– O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=CC=CC=C13
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– E1/E2/E3 Enzyme;TAM Receptor
Pathway
– Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
