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Ixazomib
Price range: 66 CAD through 1,552 CAD
Products Details
Product Description
– Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50: 31/3500 nM).
Web ID
– T2122
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H19BCl2N2O4
Citations
– 1. Chen X, Chen Y, Ou Y, et al. Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation. Biochemical Pharmacology. 2022, 206: 115326.
References
– Kupperman E, et al. Cancer Res, 2010, 70(5), 1970-80
CAS Number
– 1072833-77-2
Molecular Weight
– C14H19BCl2N2O4
Compound Purity
– 0.9818
SMILES
– CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Pathway
– Autophagy|||Apoptosis|||Ubiquitination|||Proteases/Proteasome
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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