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CX-5461

SKU T2100-1 mg Category Small Compound Brand: TargetMol

Price range: 56 CAD through 2,352 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

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Products Details

Product Description

– CX5461 is an rRNA synthesis inhibitor with oral activity that inhibits Pol I-driven rRNA transcription. CX5461 activates the DNA damage response and has antitumor activity in tumors such as ovarian cancer.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2100

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H27N7O2S

Citations

– 1. Li, Dingfeng, Juan Zhang, Ming Wang, Xiaohui Li, Huarui Gong, Huiping Tang, Lin Chen, Lili Wan, and Qiang Liu. Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation. Nature Communications. 2018, 9(1): 1-14 2. Fu Y, Liu Y, Wen T, et al. Real-time imaging of RNA polymerase I activity in living human cells. Journal of Cell Biology. 2022, 222(1): e202202110. 3. Liu T, Wu Y, Qin L, et al.Nonselective Intercalation of G-Quadruplex-Targeting Ligands into Double-Stranded DNA Quantified by Single-Molecule Stretching.The Journal of Physical Chemistry B.2023 4. Zhang Y, Cheng Y, Luo Q, et al.Distinguishing G-Quadruplexes Stabilizer and Chaperone for c-MYC Promoter G-Quadruplexes through Single-Molecule Manipulation.Journal of the American Chemical Society.2024 5. Wu Z, Xie L, Yuan P, et al.WDR68 stimulates cellular proliferation via activating ribosome biogenesis in 293T cells.Neoplasia.2024, 56: 101033.

References

– Drygin D, et al, Cancer Res, 2011, 71(4), 1418-1430.

CAS Number

– 1138549-36-6

Molecular Weight

– C27H27N7O2S

Compound Purity

– 0.9925

SMILES

– CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O

Pathway

– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.