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BCL-2/BCL-xL Inhibitor (T2099)

SKU T2099-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 102 CAD through 1,021 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

–

this BCL-2/BCL-xL inhibitor is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w (EC50=30.3 nM/78.7 nM/197.8 nM). this BCL-2/BCL-xL inhibitor exhibits antitumor activity and [skin chemistry research] activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2099

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C42H45ClN6O5S2

Citations

– 1. Zhang W, Li X, Jiang M, et al.SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.Journal of Leukocyte Biology.2023: qiad020. 2. Li R, Li Y, Jiang K, et al.Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.Cell Metabolism.2024

References

– Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic this BCL-2/BCL-xL inhibitor in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.

CAS Number

– 852808-04-9

Molecular Weight

– C42H45ClN6O5S2

Compound Purity

– 0.9973

SMILES

– CN(C)CCC(CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1

Pathway

– Autophagy|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.