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ISRIB

SKU T2027-5 mg Category Small Compound Brand: TargetMol

Price range: 77 CAD through 622 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– ISRIB is a potent and selective PERK inhibitor.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2027

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H24Cl2N2O4

Citations

– 1. Liu Y, Zou G J, Tu B X, et al. Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress. Neurotoxicity Research. 2020 2. Luhong L, mao Zhou H, han Tang X, et al.PERK inhibitor (ISRIB) improves depression-like behavior by inhibitions of HPA-axis over-activation in mice exposed to chronic restraint stress.Behavioural Brain Research.2024: 115122. 3. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024 4. Zhang C, Xu H, Tang Q, et al.CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction.EMBO reports.2024: 1-27.

References

– Sidrauski C, et al. Elife. 2013, 2, e00498.

CAS Number

– 548470-11-7

Molecular Weight

– C22H24Cl2N2O4

Compound Purity

– 0.9993

SMILES

– Clc1ccc(OCC(=O)NC2CCC(CC2)NC(=O)COc2ccc(Cl)cc2)cc1

Target

– GABA Receptor|||Endogenous Metabolite

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.