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JND4135

SKU T200291-25 mg Category Small Compound Brand: TargetMol

Price range: 3,632 CAD through 6,400 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

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Products Details

Product Description

– JND4135, a type II TRK inhibitor, exhibits IC50 values targeting TRKA, TRKB, and TRKC at 2.79, 3.19, and 3.01 nM, respectively. It can overcome resistance due to TRKxDFG and other mutations in the BaF3 stable model, inhibiting the phosphorylation of TRKs WT, xDFG mutations, and their downstream signaling molecules. Additionally, JND4135 induces G0/G1 phase arrest and cell apoptosis (apoptosis) in BaF3–CD74-TRKA-G667C cells. This compound also demonstrates antitumor activity in a BaF3-CD74-TRKA-G667C mouse xenograft model by suppressing tumor growth.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T200291

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C37H39N7O

CAS Number

– 2366216-76-2

Molecular Weight

– C37H39N7O

SMILES

– O=C(NC=1C=C(C=C(C1)C(C)C)CN2CCN(C)CC2)C=3C=CC=C(C#CC4=CN=C5C=NC(=CN45)C=6C=CC(N)=CC6)C3C

Target

– Others

Pathway

– Tyrosine Kinase/Adaptors|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.