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Cernuumolide J
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.
Products Details
Product Description
– Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.
For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.
Web ID
– T200239
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H34O8
CAS Number
– 2019163-02-9
Molecular Weight
– C24H34O8
SMILES
– O(C(C(C)C)=O)[C@@H]1[C@@]2([C@@]([C@H](OC(/C(=CC)/C)=O)C(=O)[C@H](C)CCC[C@]1(C)O)(C(=C)C(=O)O2)[H])[H]
Target
– Others
Pathway
– MAPK|||Stem Cells|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Chromatin/Epigenetic|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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