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Luminespib

SKU T1989-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 83 CAD through 1,467 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β (IC50=7.8/21 nM). Luminespib has antitumor activity and is used in studies of head and neck tumors, among others.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1989

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H31N3O5

Citations

– 1. He C X, Lv Y, Guo M, et al. Complex Crystal Structure Determination of Hsp90 N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922. Frontiers in oncology. 2022, 12: 847556-847556. 2. He C X, Lv Y, Guo M, et al. Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922. Frontiers in oncology. 2022, 12 3. Wang Y, Ma H, Huang J, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors. European Journal of Medicinal Chemistry,. 2021 Feb 15;212:113030 4. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969 5. Li J, Han X, Sun M, et al.Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity.Journal for Immunotherapy of Cancer.2023, 11(12). 6. Xu X, Xie T, Zhou M, et al.Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.Nature Communications.2024, 15(1): 4237.

References

– Eccles, Suzanne A., et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Research (2008), 68(8), 2850-2860.

CAS Number

– 747412-49-3

Molecular Weight

– C26H31N3O5

Compound Purity

– 0.9926

SMILES

– CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O

Target

– Others

Pathway

– Apoptosis|||Autophagy|||Metabolism|||Cytoskeletal Signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.