Download Files:

Capmatinib

SKU T1963-5 mg Category Small Compound Brand: TargetMol

Price range: 69 CAD through 453 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

Clear

Products Details

Product Description

– Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1963

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H17FN6O

Citations

– 1. Cao Shangtao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang et al. Chromatin accessibility dynamics during chemical induction of pluripotency. Cell Stem Cell. 2018, 22(4): 529-542. e5 2. Jiao D, Chen Y, Liu X, et al.Targeting MET endocytosis or degradation to overcome HGF-induced gefitinib resistance in EGFR-sensitive mutant lung adenocarcinoma.Biochemical and Biophysical Research Communications.2023 3. Tang J, Qi C, Bai X, et al.Cell Membrane-Anchored DNA Nanoinhibitor for Inhibition of Receptor Tyrosine Kinase Signaling Pathways via Steric Hindrance and Lysosome-Induced Protein Degradation.ACS Pharmacology & Translational Science.2023 4. Ying S, Chi H, Wu X, et al.Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer.Journal of Medicinal Chemistry.2024

References

– Liu X, et al, Clin Cancer Res, 2011, 17(227). 7127-7138.

CAS Number

– 1029712-80-8

Molecular Weight

– C23H17FN6O

Compound Purity

– 0.9924

SMILES

– CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

Target

– Others

Pathway

– Apoptosis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.